Nohno T, Sumitomo S, Ishikawa T, Ando C, Nishida S, Noji S, Saito T
Department of Pharmacology, Kawasaki Medical School, Kurashiki City, Japan.
DNA Seq. 1993;3(6):393-6. doi: 10.3109/10425179309020842.
We have isolated RPK-2 cDNA from chick embryo cDNA library that encodes a receptor protein kinase of the TGF-beta receptor subfamily. The deduced amino acid sequence reveals the presence of a hydrophobic transmembrane helix and a kinase domain distantly related to type II receptor for TGF-beta. The kinase domain sequence is most similar to RPK-1 identified recently in the chick embryo. Several cysteine residues are contained in the amino-terminal ectodomain, suggesting the protein as a receptor for a peptide growth factor of the TGF-beta family.
我们从鸡胚cDNA文库中分离出RPK - 2 cDNA，它编码一种TGF-β受体亚家族的受体蛋白激酶。推导的氨基酸序列显示存在一个疏水跨膜螺旋和一个与TGF-β II型受体远缘相关的激酶结构域。该激酶结构域序列与最近在鸡胚中鉴定出的RPK - 1最为相似。氨基末端胞外结构域含有几个半胱氨酸残基，表明该蛋白是TGF-β家族肽生长因子的受体。
