Kepes J J, Chen W Y, Jim Y F
Department of Pathology and Oncology, University of Kansas School of Medicine, Kansas City 66103.
Bone Miner. 1993 Jul;22(1):33-41. doi: 10.1016/s0169-6009(08)80079-7.
Polyvinylpyrrolidone (PVP) has been used in industry as well as in medicine for various purposes, e.g. as a component of hair-sprays, 'retardant' for subcutaneous injections, and given intravenously as a plasma expander. The latter usage results in deposition of PVP in the reticulo-endothelial system and other mesenchymal cells, including osteocytes. A middle aged woman in Taiwan, who for 10 years received repeated intravenous injections of PVP, suffered pathologic fractures of both femora and her right humerus with additional destructive lesions seen radiologically in other bones. Biopsies of the fracture sites showed both intracellular PVP deposits and mucoid changes in the involved cells, a characteristic secondary complication of PVP deposition. This phenomenon, if of sufficient severity, may cause, as in this case, a virtual 'melting down' of osseous tissue with pathological fractures as a consequence.
聚乙烯吡咯烷酮（PVP）已在工业和医学领域用于多种用途，例如作为发胶的成分、皮下注射的“阻滞剂”，以及静脉注射作为血浆扩容剂。后一种用法会导致PVP沉积在网状内皮系统和其他间充质细胞中，包括骨细胞。台湾一名中年女性，10年来反复接受PVP静脉注射，双侧股骨和右肱骨发生病理性骨折，其他骨骼在放射学上可见额外的破坏性病变。骨折部位的活检显示，受累细胞内既有PVP沉积，又有黏液样改变，这是PVP沉积的典型继发性并发症。这种现象如果足够严重，可能会像本例一样，导致骨组织几乎“溶解”，进而引发病理性骨折。
