Intracellular mucoid changes in tumor cells of meningiomas: a manifestation of polyvinylpyrrolidone (PVP) effect on tissues with mesenchymal characteristics.

In two cases of meningiomas in Taiwanese patients, extensive intracellular mucoid changes were found within tumor cells, together with deposits of polyvinylpyrrolidone (PVP) granules. Both patients had in the past received intravenous PVP as a plasma expander. Recipients of PVP have previously been reported to develop a form of PVP thesaurismosis with concomitant mucoid changes in the cells storing this substance. Such changes, as a rule, were limited to cells of mesenchymal origin. By storing PVP granules and undergoing mucoid changes as a result, meningioma tumor cells behave as cells with mesenchymal characteristics.