[奎尼丁、三甲卡因、乙胺碘呋酮、普萘洛尔和维拉帕米聚合物形式的抗心律失常活性]
[The antiarrhythmic activity of the polymeric forms of quinidine, trimecaine, etatsizin, propranolol and verapamil].
作者信息
Sidorenko G I, Gurin A V, Koliadko M G, Iurkshtovich T L, Nedorezov V L
出版信息
Eksp Klin Farmakol. 1993 May-Jun;56(3):27-30.
The antiarrhythmic activity and acute toxicity of polymeric formulations of quinidine, trimecaine, ethacizine, propranolol, verapamil which had been immobilized on a cellulose carrier (monocarboxylcellulose) and low molecular analogues were studied in various experimental animals (rats, mice, dogs). The polymeric formulations of trimecaine and verapamil were found to have a higher antiarrhythmic activity in different arrhythmia models than trimecaine and verapamil. The toxicity of all new compounds was no more than the values of conventional antiarrhythmic drugs.
研究了固定在纤维素载体（单羧基纤维素）上的奎尼丁、三甲卡因、乙胺碘呋酮、普萘洛尔、维拉帕米的聚合物制剂及其低分子类似物在各种实验动物（大鼠、小鼠、狗）中的抗心律失常活性和急性毒性。发现在不同的心律失常模型中，三甲卡因和维拉帕米的聚合物制剂比三甲卡因和维拉帕米具有更高的抗心律失常活性。所有新化合物的毒性不超过传统抗心律失常药物的值。
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