Plotnikova T M, Firsov N N, Saratikov A S
Eksp Klin Farmakol. 1993 May-Jun;56(3):35-7.
The new calcium antagonist cerebrocrast intravenously infused in a dose of 0.4 micrograms.kg-1.min-1 during 15 min prevented erythrocyte deformability disturbances at the end of cerebral ischemia in rats, which was induced by carotid artery occlusion during 30 min. The agents also prevented the deformability 1 hour after the onset of recirculation. Cerebrocrast reduced spontaneous erythrocyte aggregation, the strength of erythrocytic aggregates, and hemoglobin affinity for oxygen. The latter effect was associated with the drug-induced increase in erythrocytic 2,3-diphosphoglycerate levels.
新型钙拮抗剂脑压宁以0.4微克·千克⁻¹·分钟⁻¹的剂量静脉输注15分钟，可预防大鼠大脑缺血结束时红细胞变形能力的紊乱，该大脑缺血是由颈动脉闭塞30分钟诱导产生的。该药物还可预防再灌注开始1小时后的红细胞变形能力。脑压宁可降低自发性红细胞聚集、红细胞聚集体的强度以及血红蛋白对氧的亲和力。后一种作用与药物诱导的红细胞2,3-二磷酸甘油酸水平升高有关。
