Bazhenova T G, Plotnikov M B, Plotnikova T M, Saratikov A S
Biull Eksp Biol Med. 1992 Oct;114(10):378-80.
Acute cerebral ischemia in cats (both carotid arteries occlusion during 30 min after permanent occlusion of both vertebral arteries) was accompanied by postischemic hypoperfusion and hypo-oxygenation of the cerebral tissue. Intravenous infusion of cerebrocrast (1 micrograms.kg-1.min-1 during 60 min) prevented manifestation of the postischemic phenomena. Antihypoxic effect of cerebrocrast involved the cerebral blood flow increase, brain oxygen consumption lowering and Hb-O2-affinity decrease.
猫的急性脑缺血(在双侧椎动脉永久性闭塞后30分钟内双侧颈动脉闭塞)伴有缺血后脑组织灌注不足和氧合不足。静脉输注脑复康(60分钟内1微克·千克⁻¹·分钟⁻¹)可预防缺血后现象的出现。脑复康的抗缺氧作用包括增加脑血流量、降低脑氧耗量以及降低血红蛋白与氧的亲和力。