Nakamura N, Nojima T, Inoue K, Terasaka S, Aida T, Abe H
Department of Laboratory Technology, College of Medical Technology, Hokkaido University.
Noshuyo Byori. 1993;10(2):99-101.
We report a case of meningioma with secretory features in a 47-year-old woman. The left frontal tumor mass had already eroded the overlying bone at the time of presentation. When respected, the mass showed a gelatinous appearance. Histologically, marked vacuolar change was seen in the stroma. Whorls, psammoma bodies, and pavement arrangement of nuclei were also noted. Periodic acid-Schiff stain revealed cytoplasmic granules, which were digested with diastase. Alcian blue diffusely stained the cytoplasm of the tumor cells. Electron microscopy showed numerous small vacuoles and cored vesicles in the cytoplasm. Glycogen granules were poorly observed. These features indicate the mild secretory nature of this vacuolated meningioma.
我们报告一例47岁女性的具有分泌特征的脑膜瘤。就诊时，左额叶肿瘤肿块已侵蚀上方骨质。触摸时，肿块呈凝胶状外观。组织学上，间质可见明显的空泡样改变。还可见漩涡状结构、砂粒体及细胞核的铺石状排列。过碘酸希夫染色显示胞质内颗粒，用淀粉酶消化后消失。阿尔辛蓝弥漫性染色肿瘤细胞的胞质。电镜显示胞质内有许多小空泡和有芯小泡。糖原颗粒少见。这些特征表明该空泡状脑膜瘤具有轻度分泌性质。
