Utsuki S, Kawano N, Oka H, Suwa T, Fujii K, Iwabuchi K, Yagishita S
Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Clin Neuropathol. 1998 Jul-Aug;17(4):216-20.
A 55-year-old man presented with a frontal mass lesion, which histologically consisted of pleomorphic tumor cells with necrotic foci and abundant mitotic figures, showing a meningothelial pattern focally. In addition, many eosinophilic round- or irregular-shaped bodies were seen not only in tumor cell cytoplasm but also in between the tumor cells. By electron microscopy, the tumor cells showed a minimal adherence to each other and the intercellular spaces were wide. Tumor cells had numerous branching cytoplasmic processes and some of them were united by desmosomal junctions. These features suggested that the tumor was a malignant variety of arachnoid trabecular cell meningioma. The inclusion bodies consisted of homogeneous fine granular material and were not surrounded by microvilli. This type of inclusion body has not been reported in meningiomas in the past. The significance and possible pathogenesis of the inclusions are discussed.
一名55岁男性出现额部肿块病变，组织学检查显示由多形性肿瘤细胞组成，伴有坏死灶和丰富的有丝分裂象，局部呈脑膜内皮型。此外，不仅在肿瘤细胞胞质内，而且在肿瘤细胞之间可见许多嗜酸性圆形或不规则形小体。电镜下，肿瘤细胞彼此间粘附性极小，细胞间隙较宽。肿瘤细胞有许多分支状胞质突起，其中一些通过桥粒连接相连。这些特征提示该肿瘤为蛛网膜小梁细胞型脑膜瘤的恶性变种。包涵体由均匀的细颗粒物质组成，未被微绒毛围绕。过去在脑膜瘤中尚未报道过这种类型的包涵体。文中讨论了包涵体的意义及可能的发病机制。
