Kawagoe J, Abe K, Aoki M, Kogure K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Brain Res. 1993 Sep 3;621(1):121-5. doi: 10.1016/0006-8993(93)90306-8.
Distribution of heat shock protein (HSP) 90 alpha mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90 alpha mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90 alpha mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90 alpha mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90 alpha with other HSPs after ischemia.
通过原位杂交技术研究了沙土鼠海马在短暂全脑缺血10分钟后热休克蛋白（HSP）90α mRNA诱导的分布情况。海马细胞中通常存在少量HSP90α mRNA，缺血后8小时该mRNA进一步诱导并达到峰值。在易受缺血影响的海马CA1区细胞中，HSP90α mRNA持续诱导1天，最终在2天时减少。海马CA1区细胞中HSP90α mRNA诱导的时间模式与先前报道的HSP70 mRNA相似，提示缺血后HSP90α与其他热休克蛋白发挥协同作用。
