Lewis R A, Hultquist D E, Baker B L, Falls H F, Gershowitz H, Penner J A
J Lab Clin Med. 1976 Sep;88(3):375-88.
Although copper is an essential constituent of many physiologic systems, most human diseases effect minimal changes in copper homeostasis. Therefore, the association of marked hypercupremia with copper deposition in the ocular media and with a circulating immunoglobulin G in an apparently healthy woman prompted our interest. Balance and radioisotopic studies suggest a normal gastrointestinal and renal threshold for copper but a specific and tight binding between the serum copper and the anomalous protein, the probable result of a preclinical myeloma. Because the response of the hypercupremia to chelation therapy was limited, the multiple myeloma was treated with cytoxic drugs.
尽管铜是许多生理系统的必需成分，但大多数人类疾病对铜稳态的影响极小。因此，在一名看似健康的女性中，明显的高铜血症与眼内介质中的铜沉积以及循环免疫球蛋白G相关联，这引起了我们的兴趣。平衡和放射性同位素研究表明，铜的胃肠道和肾脏阈值正常，但血清铜与异常蛋白之间存在特异性紧密结合，这可能是临床前骨髓瘤的结果。由于高铜血症对螯合疗法的反应有限，因此用细胞毒性药物治疗多发性骨髓瘤。
