去极化蛙心室中的自发机械活动。
Spontaneous mechanical activity in depolarized frog ventricle.
作者信息
Winegrad S
出版信息
J Gen Physiol. 1976 Aug;68(2):145-57. doi: 10.1085/jgp.68.2.145.
Abstract
Spontaneous mechanical activity can be produced in depolarized frog ventricle by bathing the tissue in a solution with low Na, Iow Ca, and high K+. The contractions can be inhibited by depleting the tissue of Ca first, but they are relatively insensitive to changes in either extracellular [Ca++] or [Ca++]/[Na+]2. They are terminated very rapidly by raising [Na+] to 40 mM. Local anesthetics enhance the spontaneous activity in proportion to the concentration of their free base form. These contractions occur relatively rhythmically for several hours. Since the preparation is multicellular, this suggests a mechanism for intercellular communication without change in membrane potential.
摘要
通过将青蛙心室组织浸泡在低钠、低钙和高钾离子的溶液中，可以使其产生自发机械活动。首先耗尽组织中的钙可以抑制收缩，但它们对细胞外[Ca++]或[Ca++]/[Na+]2的变化相对不敏感。将[Na+]提高到40 mM可使其迅速终止。局部麻醉剂按其游离碱形式的浓度比例增强自发活动。这些收缩会相对有节律地持续几个小时。由于该制备物是多细胞的，这表明存在一种细胞间通讯机制，且膜电位无变化。
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