Benouali S, Sarda N, Gharib A, Roche M
Université de Savoie, Physiologie et Pharmacologie Appliquées, Chambéry, France.
C R Acad Sci III. 1993;316(5):524-8.
In the interdigestive period, intestinal motility displays myoelectrical complexes occurring cyclically at a constant rhythm. Since it is established that the pineal gland plays an important role in the control of circadian rhythms via its melatonin secretion, we decided to study the effects of pinealectomy and melatonin on the organization of the ileo-ceco-colic electromyogram of the rat. Pinealectomy resulted in the disappearance of ileal myoelectrical complexes and, concurrently, an excitomotor effect on the cecocolic tract. In pinealectomized rats a single intravenous injection of melatonin during lighting period induced an immediate recovery of the ileal myoelectrical complexes and a progressive return to the control electromyographic pattern of the ceco-colic tract. The melatonin action was definitive.
在消化间期，肠道运动表现出以恒定节律周期性发生的肌电复合波。由于已经确定松果体通过其褪黑素分泌在昼夜节律的控制中起重要作用，我们决定研究松果体切除和褪黑素对大鼠回盲结肠肌电图组织的影响。松果体切除导致回肠肌电复合波消失，同时对盲结肠段产生兴奋运动作用。在光照期间，对松果体切除的大鼠单次静脉注射褪黑素可立即恢复回肠肌电复合波，并使盲结肠段逐渐恢复到对照肌电图模式。褪黑素的作用是决定性的。
