Li C M, Lei D N
Department of Pathology, Beijing Medical University.
Zhonghua Yi Xue Za Zhi. 1993 May;73(5):283-5, 319.
Three lectins (PNA, PHA, dBA) were used to study gastric carcinoma (66 cases), lymph node metastatic tumors (32), normal gastric mucosa (10), dysplasia (30), and intestinal metaplasia with gastritis (43). The intestinal metaplasia with quite abundant PHA and DBA receptors was closely related to gastric carcinoma. The positive rate of PHA receptors increased progressively in order of mild dysplasia, moderate dysplasia, severe dysplasia and gastric carcinoma. The distribution of PHA and PNA receptors was correlated with the histologic type and the degree of differentiation. 81.3% lymph node metastatic tumors produced cellular glycoconjugates, which differed in lectin binding profiles from those made by the cells in the respectively primary carcinoma. More PHA receptors were produced by the lymph node metastatic tumors than primary carcinoma.
使用三种凝集素（PNA、PHA、dBA）对66例胃癌、32例淋巴结转移瘤、10例正常胃黏膜、30例发育异常及43例伴有胃炎的肠化生进行研究。具有相当丰富PHA和DBA受体的肠化生与胃癌密切相关。PHA受体阳性率按轻度发育异常、中度发育异常、重度发育异常和胃癌的顺序逐渐升高。PHA和PNA受体的分布与组织学类型及分化程度相关。81.3%的淋巴结转移瘤产生细胞糖缀合物，其凝集素结合谱与相应原发性癌的细胞所产生的不同。淋巴结转移瘤产生的PHA受体比原发性癌更多。
