Kern M J, Wolford T, Donohue T J, Bach R G, Aguirre F V, Caracciolo E A, Flynn M S
Department of Internal Medicine, St. Louis University Medical Center, Missouri.
Cathet Cardiovasc Diagn. 1993 Aug;29(4):329-34. doi: 10.1002/ccd.1810290419.
In the course of studying the effects of coronary angioplasty on branch vessel flow using two Doppler flow velocity guidewires, we quantitated simultaneous blood flow responses proximal and distal to a stenosis. The alterations of flow documented a horizontal epicardial steal induced during dipyridamole hyperemia, hyperemic flow reversal by intravenous aminophylline, and subsequent normalization of distal hyperemia after endoluminal enlargement by successful angioplasty. The quantitative physiology of the patient described here confirms one postulated mechanism of abnormal myocardial perfusion stress scintigraphy. Continuous dual flowire spectral coronary flow determinations appear to be a valuable method in verifying postulated mechanisms of various pharmacologic and mechanical stimuli influencing coronary blood flow in patients with atherosclerotic coronary artery disease.
在使用两根多普勒血流速度导丝研究冠状动脉成形术对分支血管血流影响的过程中，我们对狭窄近端和远端的同步血流反应进行了定量分析。记录的血流变化显示，双嘧达莫充血期间诱发了水平心外膜窃血，静脉注射氨茶碱后充血血流逆转，成功进行血管成形术使管腔扩张后远端充血随后恢复正常。此处描述的患者定量生理学证实了心肌灌注应激闪烁显像的一种推测机制。连续双导丝频谱冠状动脉血流测定似乎是一种有价值的方法，可用于验证影响动脉粥样硬化性冠状动脉疾病患者冠状动脉血流的各种药理和机械刺激的推测机制。
