Bohenek W S, Johnson C A, Ateshkadi A, Oxton L L, Zimmerman S W
Department of Pharmaceutical Services, University of Chicago Hospitals, IL.
Clin Pharm. 1993 Aug;12(8):602-5.
The effect of peritonitis on plasma and dialysate alpha 1-acid glycoprotein (AAG) concentrations was determined. Plasma and dialysate samples were obtained at the onset of infection and one month after treatment from 10 peritoneal dialysis patients with peritonitis. Plasma and dialysate samples were also obtained from 10 noninfected matched controls. Sampling was repeated after a minimum of one month. Samples were assayed for AAG by radial immunodiffusion. The mean +/- S.D. plasma AAG concentrations for patients with peritonitis and for control patients were 152.4 +/- 30.9 mg/dL and 146.6 +/- 45.0 mg/dL, respectively (p > 0.05). The dialysate AAG concentrations for nine control patients were below the limit of detection. The mean +/- S.D. dialysate concentration for the nine infected patients with detectable AAG concentrations was 15.4 +/- 9.5 mg/dL. After successful antimicrobial therapy, dialysate AAG concentrations declined. There was no obvious correlation between dialysate white blood cell count and dialysate AAG concentration during peritonitis. Peritonitis increased dialysate AAG concentrations but had no effect on plasma AAG concentrations.
测定了腹膜炎对血浆和透析液中α1-酸性糖蛋白（AAG）浓度的影响。从10例患有腹膜炎的腹膜透析患者身上，在感染发作时和治疗后1个月采集血浆和透析液样本。还从10名匹配的未感染对照者身上采集血浆和透析液样本。至少1个月后重复采样。通过放射免疫扩散法测定样本中的AAG。腹膜炎患者和对照患者的血浆AAG平均浓度±标准差分别为152.4±30.9mg/dL和146.6±45.0mg/dL（p>0.05）。9名对照患者的透析液AAG浓度低于检测限。9名AAG浓度可检测的感染患者的透析液平均浓度±标准差为15.4±9.5mg/dL。成功的抗菌治疗后，透析液AAG浓度下降。腹膜炎期间，透析液白细胞计数与透析液AAG浓度之间无明显相关性。腹膜炎会增加透析液AAG浓度，但对血浆AAG浓度无影响。
