Lattanzi A
Ospedale S. Chiara di Pisa.
Clin Ter. 1993 Sep;143(3):191-9.
Having briefly recalled the chemical structure of glycosamine glycans (GAG) and the therapeutic use of standard heparin at conventional doses (anticoagulant action) and at low dosage (antithrombotic action), the properties and therapeutic employment of low molecular weight heparins (LMWH) are illustrated, and their advantages and disadvantages compared to standard heparin are discussed. Subsequently, the characteristics of heparan sulfates and other GAGs of the vascular endothelium and their therapeutic properties are described. Finally, GAGs found in articular structures are also mentioned.
在简要回顾了氨基聚糖(GAG)的化学结构以及标准肝素在常规剂量下的治疗用途(抗凝作用)和低剂量下的治疗用途(抗血栓形成作用)之后,阐述了低分子量肝素(LMWH)的特性和治疗应用,并讨论了其与标准肝素相比的优缺点。随后,描述了硫酸乙酰肝素和血管内皮的其他GAG的特性及其治疗特性。最后,还提到了关节结构中发现的GAG。