Mooij P, Drexhage H A
Department of Immunology, Erasmus University Rotterdam, The Netherlands.
Clin Lab Med. 1993 Sep;13(3):683-97.
A considerable proportion of the thyroid diseases is due to aberrant immune reactions toward thyroid antigens. Autoreactivity is considered to be a normal process controlled by several suppressor mechanisms. Malfunction of these suppressor mechanisms may result in autoimmune disease. Mechanisms of self-tolerance, defects in autoimmune disease, thyroid autoantibodies, thyroid autoreactive T cells, several thyroid autoimmune diseases, and the role of iodine in thyroid autoimmune reactivity are addressed.
相当一部分甲状腺疾病是由于对甲状腺抗原的异常免疫反应所致。自身反应性被认为是一个由多种抑制机制控制的正常过程。这些抑制机制的功能失调可能导致自身免疫性疾病。本文探讨了自身耐受机制、自身免疫性疾病中的缺陷、甲状腺自身抗体、甲状腺自身反应性T细胞、几种甲状腺自身免疫性疾病以及碘在甲状腺自身免疫反应性中的作用。
