Eichhorn M, Lütjen-Drecoll E
Department of Anatomy, University of Erlangen-Nürnberg, Germany.
Curr Eye Res. 1993 Aug;12(8):753-7. doi: 10.3109/02713689308995771.
In primate eyes the injection of Endothelin (ET) 1 into the anterior chamber lowers the intraocular pressure by increasing outflow facility. A possible source for aqueous ET is the ciliary epithelium, since virus transformed human nonpigmented ciliary epithelial cells secrete ET into the medium and immunohistochemically stain with antibodies against ET 1. This study demonstrates that human ciliary epithelium exhibits positive endothelin-like immunoreactivity with antibodies against ET 1. There are, however, regional differences with regard to the staining intensity. Pronounced staining was observed in the nonpigmented and pigmented epithelium at the crests of the pars plicata. In the valleys of the pars plicata and in the pars plana no immunolabeling was found.
在灵长类动物眼中，向前房注射内皮素（ET）-1可通过增加房水流出易度来降低眼压。房水ET的一个可能来源是睫状体上皮，因为病毒转化的人非色素睫状上皮细胞可将ET分泌到培养基中，并且用抗ET-1抗体进行免疫组织化学染色呈阳性。本研究表明，人睫状体上皮用抗ET-1抗体显示出内皮素样免疫反应阳性。然而，在染色强度方面存在区域差异。在褶部嵴处的非色素上皮和色素上皮中观察到明显染色。在褶部谷底和平坦部未发现免疫标记。
