Petersen C S, Weismann K, Avnstorp C, Rasmussen L P, Fogh H, Tikjøb G
Department of Dermato-Venerology, Bispebjerg Hospital, Copenhagen.
Dan Med Bull. 1993 Sep;40(4):506-7.
A randomised double-blind placebo controlled trial was performed to assess the efficacy and safety of tromantadine ointment 1% in male patients with genital herpes. 45 patients with penile genital herpes of less than three days duration were randomised to local treatment with tromantadine ointment 1% or placebo (ointment base alone) five times daily up to 12 days. No difference in time of healing could be detected between the two groups (p = 1.0). Both the objective signs (vesicles, pustules, ulceration, and glandular swelling) and the subjective symptoms (itching, burning, pain and dysuria) all diminished simultaneously in the two groups.
进行了一项随机双盲安慰剂对照试验，以评估1%曲金刚胺软膏对男性生殖器疱疹患者的疗效和安全性。45例病程少于3天的阴茎生殖器疱疹患者被随机分为两组，一组接受1%曲金刚胺软膏局部治疗，另一组接受安慰剂（仅软膏基质）局部治疗，均为每日5次，持续12天。两组之间未检测到愈合时间的差异（p = 1.0）。两组的客观体征（水疱、脓疱、溃疡和腺体肿胀）和主观症状（瘙痒、灼痛、疼痛和排尿困难）均同时减轻。
