Edwards R, Brown J, Greenwood D
Department of Microbiology, Queen's Medical Centre, Nottingham, UK.
Chemotherapy. 1993 Nov-Dec;39(6):390-3. doi: 10.1159/000238982.
The activity of meropenem was similar to that of imipenem against 88 clinical isolates of Bacteroides spp., including 28 non-fragilis strains. Four of the isolates were able to hydrolyse cephamycins or penems. Investigation of beta-lactamases from these strains and 10 laboratory stock culture Bacteroides showed that meropenem and imipenem were degraded at a similar rate by cell-free preparations of these enzymes. Some of these strains were able to completely hydrolyse the carbapenems within 2 h. Despite this rapid hydrolysis, MICs of meropenem and imipenem for some of the strains remained within the susceptible range as judged by agar dilution titration.
美罗培南对88株拟杆菌属临床分离株（包括28株非脆弱拟杆菌菌株）的活性与亚胺培南相似。其中有4株分离株能够水解头孢霉素或青霉烯类。对这些菌株和10株实验室保藏培养的拟杆菌的β-内酰胺酶进行研究发现，这些酶的无细胞制剂对美罗培南和亚胺培南的降解速率相似。其中一些菌株能够在2小时内完全水解碳青霉烯类。尽管有这种快速水解，但通过琼脂稀释滴定法判断，美罗培南和亚胺培南对其中一些菌株的最低抑菌浓度仍在敏感范围内。
