Andrew J H, Greenwood D
J Antimicrob Chemother. 1987 May;19(5):591-5. doi: 10.1093/jac/19.5.591.
Eight strains of the Bacteroides fragilis group that produce unusual beta-lactamases were used to investigate the activity and susceptibility to hydrolysis of cefotetan, a new cephamycin and Sch 34343, a new penem. Cefoxitin and imipenem were also examined for comparison. Antibiotic titrations revealed that cefotetan was less active than cefoxitin against four of the eight strains, and that Sch 34343 was as active or more active than imipenem. Crude enzyme extracts degraded cefotetan more quickly than cefoxitin as judged by high pressure liquid chromatography. Three of the extracts were able to degrade imipenem completely within 1 h and these enzymes degraded Sch 34343 even more rapidly.
使用八株能产生异常β-内酰胺酶的脆弱拟杆菌属菌株，研究新型头孢霉素头孢替坦和新型青霉烯类药物Sch 34343的活性及对水解的敏感性。同时检测头孢西丁和亚胺培南作为对照。抗生素滴定显示，头孢替坦对八株菌中的四株活性低于头孢西丁，且Sch 34343的活性与亚胺培南相当或更高。通过高压液相色谱判断，粗酶提取物降解头孢替坦比降解头孢西丁更快。其中三份提取物能够在1小时内完全降解亚胺培南，且这些酶降解Sch 34343的速度更快。
