Davies N, Kynaston H, Yates J, Nott D M, Jenkins S A, Taylor B A
University Department of Surgery, University of Liverpool, United Kingdom.
Dis Colon Rectum. 1993 Nov;36(11):1054-8. doi: 10.1007/BF02047299.
Levamisole in combination with 5-fluorouracil is an effective adjuvant for the treatment of resected Dukes stage C colon cancer. Since the mechanism of action of levamisole is not known, we have investigated its effects on hepatic and splenic reticuloendothelial system (RES) activity in the rat and compared the effect of levamisole with other known RES stimulators.
The hepatic and splenic uptake of an intravenous dose of technetium-99m-sulfur colloid has been used to measure RES activity in rats treated with levamisole, glucan, zymosan, chlormethiazole, octreotide, and saline.
Levamisole significantly increased the hepatic uptake of technetium-99m-sulfur colloid and is comparable in its effect to the other RES stimulators. In contrast, levamisole has no effect on splenic RES activity.
RES function is considered to be a potentially important factor in the development of liver metastases, and the stimulatory effect of levamisole on the hepatic RES may partly explain its efficacy as an adjuvant treatment in colon cancer.
左旋咪唑联合5-氟尿嘧啶是治疗 Dukes C 期结肠癌切除术后的一种有效辅助药物。由于左旋咪唑的作用机制尚不清楚，我们研究了其对大鼠肝脏和脾脏网状内皮系统（RES）活性的影响，并将左旋咪唑的作用与其他已知的RES刺激剂进行了比较。
静脉注射99m锝-硫胶体后，通过测量肝脏和脾脏对其的摄取量，来检测用左旋咪唑、葡聚糖、酵母聚糖、氯美噻唑、奥曲肽和生理盐水处理的大鼠的RES活性。
左旋咪唑显著增加了肝脏对99m锝-硫胶体的摄取，其效果与其他RES刺激剂相当。相比之下，左旋咪唑对脾脏RES活性没有影响。
RES功能被认为是肝转移发生中一个潜在的重要因素，左旋咪唑对肝脏RES的刺激作用可能部分解释了其作为结肠癌辅助治疗药物的疗效。
