Baxter J N, Jenkins S A, Day D W, Shields R
Br J Surg. 1985 Dec;72(12):1005-8. doi: 10.1002/bjs.1800721224.
The effects of a long acting somatostatin analogue, SMS 201-995, on reticulo-endothelial system (RES) activity were studied in rats. Administration of 2 micrograms SMS 201-995 subcutaneously twice a day for 7 days significantly increased the splenic and hepatic uptake of 99mTc-sulphur colloid and damaged 51mCr-red blood cells. Furthermore, SMS 201-995 administration significantly increased the plasma clearance of colloidal carbon as indicated by a lower area under the curve and an increased elimination constant. SMS 201-995 administration also significantly improved survival after intraperitoneal injection of Escherichia coli endotoxin. These results suggest that SMS 201-995 stimulates RES activity in rats. It is suggested that SMS 201-995 may be of value in stimulating RES activity in patients with cirrhosis and portal hypertension.
在大鼠中研究了长效生长抑素类似物SMS 201-995对网状内皮系统（RES）活性的影响。每天两次皮下注射2微克SMS 201-995，连续7天，显著增加了脾脏和肝脏对99mTc-硫胶体的摄取，并破坏了51mCr-红细胞。此外，如曲线下面积降低和消除常数增加所示，注射SMS 201-995显著增加了胶体碳的血浆清除率。注射SMS 201-995还显著提高了腹腔注射大肠杆菌内毒素后的存活率。这些结果表明，SMS 201-995可刺激大鼠的RES活性。提示SMS 201-995在刺激肝硬化和门静脉高压患者的RES活性方面可能具有价值。
