Applegate C D, Samoriski G M
Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642.
Epilepsy Res. 1993 Jul;15(3):201-5. doi: 10.1016/0920-1211(93)90057-e.
Investigations into the neurochemical or molecular biological mechanisms underlying the kindled state require a seizure induction procedure for eliciting generalized tonic-clonic seizures in naive animals. Such seizure controls are necessary for dissociating the influence of ictal motor events on measures of interest from the influence of the kindling process on these same measures. In this study three procedures for inducing seizures in naive animals were evaluated against a set of criteria considered ideal.
对点燃状态下潜在的神经化学或分子生物学机制进行研究，需要一种癫痫诱导程序，以便在未发作过癫痫的动物中引发全身性强直阵挛性癫痫发作。这种癫痫控制对于区分发作期运动事件对感兴趣指标的影响与点燃过程对这些相同指标的影响是必要的。在本研究中，根据一套被认为理想的标准，对三种在未发作过癫痫的动物中诱导癫痫发作的程序进行了评估。
