Kaneko K, Igarashi J, Suzuki Y, Niijima S, Ishimoto K, Yabuta K
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Eur J Pediatr. 1993 Sep;152(9):769-70. doi: 10.1007/BF01953999.
A rare case of carbamazepine-induced leucopenia and thrombocytopenia complicated by Henoch-Schönlein purpura (HSP) symptoms is presented. Laboratory findings suggested that leucopenia and thrombocytopenia could be due to bone marrow suppression and HSP symptoms to an allergic reaction to carbamazepine. To the best of our knowledge this is the first report that carbamazepine may cause haematological disorders associated with symptoms of HSP by different mechanisms at the same time in the same patient.
本文报告了一例罕见的卡马西平诱发白细胞减少和血小板减少并伴有过敏性紫癜（HSP）症状的病例。实验室检查结果表明，白细胞减少和血小板减少可能是由于骨髓抑制，而HSP症状则是对卡马西平的过敏反应所致。据我们所知，这是首例关于卡马西平可在同一患者体内同时通过不同机制导致血液系统疾病并伴有HSP症状的报告。
