Furukawa S, Matsubara T, Yone K, Hirano Y, Okumura K, Yabuta K
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Eur J Pediatr. 1992 Jan;151(1):44-7. doi: 10.1007/BF02073890.
It has been reported that tumour necrosis factor-alpha (TNF-alpha) is capable of inducing vascular injury, and interleukin 6 (IL-6) of inducing production of acute phase proteins and the maturation of megakaryocytes. Kawasaki disease (KD) is a systemic vasculitis with severe inflammation. We investigated whether TNF-alpha and IL-6 activities in serum from patients with KD differs from those in anaphylactoid purpura (AP) and measles. Serum TNF-alpha levels were measured by a sandwich enzyme immunoassay and IL-6 activities in serum were assessed by a colorimetric assay. Both KD and AP patients but not patients with measles had increased serum TNF-alpha levels during the acute stage. With respect to IL-6, patients with KD and measles, but not AP, had increased IL-6 activities in serum during the acute stage. IL-6 activities in serum of KD patients correlated with serum C-reactive protein levels and correlated to some extent with maximum platelet counts during the course of illness. These results suggest that KD differs from AP and measles regarding both cytokines. The combination of TNF-alpha, which may be responsible for severe vascular injury, and IL-6, which may be responsible for severe inflammation, may play an important role in acute KD.
据报道，肿瘤坏死因子-α（TNF-α）能够诱导血管损伤，白细胞介素6（IL-6）能够诱导急性期蛋白的产生以及巨核细胞的成熟。川崎病（KD）是一种伴有严重炎症的系统性血管炎。我们研究了KD患者血清中的TNF-α和IL-6活性是否与过敏性紫癜（AP）和麻疹患者不同。采用夹心酶免疫测定法测量血清TNF-α水平，采用比色测定法评估血清中的IL-6活性。KD和AP患者在急性期血清TNF-α水平均升高，但麻疹患者未升高。关于IL-6，KD和麻疹患者在急性期血清中的IL-6活性升高，但AP患者未升高。KD患者血清中的IL-6活性与血清C反应蛋白水平相关，并且在病程中与最大血小板计数在一定程度上相关。这些结果表明，KD在两种细胞因子方面与AP和麻疹不同。可能导致严重血管损伤的TNF-α与可能导致严重炎症的IL-6的联合作用可能在急性KD中起重要作用。
