蟾毒灵是蟾蜍毒液中的一种化合物，可阻断心肌细胞中的钠钾泵电流。
Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes.
作者信息
Cruz J dos S, Matsuda H
机构信息
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6. doi: 10.1016/0014-2999(93)90999-x.
PMID:8223897
Abstract
The effects of arenobufagin, a bufadienolide isolated from toad venom, on the Na+/K+ pump were investigated by recording the whole-cell current of dissociated cardiac myocytes. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1. Arenobufagin is 3.5-fold more potent than ouabain.
摘要
通过记录解离心肌细胞的全细胞电流，研究了从蟾蜍毒液中分离出的蟾毒配基类强心甾体化合物华蟾毒精对Na+/K+泵的作用。华蟾毒精以剂量依赖性方式阻断Na+/K+泵电流，半数最大浓度为0.29微摩尔，希尔系数为1.1。华蟾毒精的效力比哇巴因高3.5倍。
Zotero 插件