Henkel R D, Sharp R M, Galindo L V, Aivaliotis M J, Carey K D, McGill H C, VandeBerg J L
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
Exp Mol Pathol. 1993 Oct;59(2):111-21. doi: 10.1006/exmp.1993.1032.
We have characterized the expression of allelic variants of X-linked glucose 6-phosphate dehydrogenase (G6PD) in aorta from homozygous, hemizygous, and heterozygous baboons (Papio hamadryas). Fibrous plaques from heterozygous baboons fed a high cholesterol, saturated fat diet contained distributions of G6PD allelic variants that differed from those of normal arterial wall and fatty streaks. The skewed allelic expression patterns in fibrous plaques of heterozygotes reflect decreased cellular heterogeneity in advanced vascular lesions. The tendency toward cellular monotypism in fibrous plaques is similar to that present in advanced human atherosclerotic lesions. Our results suggest that G6PD heterozygous baboons are a unique primate model for investigating the cellular origin of proliferating smooth muscle cells in atherosclerotic plaques.
我们已经对纯合子、半合子和杂合子狒狒（阿拉伯狒狒）主动脉中X连锁葡萄糖6磷酸脱氢酶（G6PD）等位基因变体的表达进行了表征。喂食高胆固醇、饱和脂肪饮食的杂合子狒狒的纤维斑块中G6PD等位基因变体的分布与正常动脉壁和脂肪条纹的不同。杂合子纤维斑块中偏斜的等位基因表达模式反映了晚期血管病变中细胞异质性的降低。纤维斑块中细胞单型性的趋势与晚期人类动脉粥样硬化病变中存在的趋势相似。我们的结果表明，G6PD杂合子狒狒是研究动脉粥样硬化斑块中增殖平滑肌细胞的细胞起源的独特灵长类动物模型。
