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Comparative autoradiographic and metabolic study of delta8- and delta9-tetrahydrocannabinol in the brain of the marmoset Callithrix jacchus.

作者信息

Erdmann G, Just W W, Thel S, Werner G, Wiechmann M

出版信息

Psychopharmacology (Berl). 1976 May 5;47(1):53-8. doi: 10.1007/BF00428701.

DOI:10.1007/BF00428701
PMID:822439
Abstract

The label distribution in the brain of the marmoset Callithrix jacchus following intravenous application of radioactively labeled delta8-tetrahydrocannabinol (delta8-THC) and delta9-THC is investigated by autoradiographic technique. Accumulations of label are observed in nuclei concerned with motor function, in the optic and acoustic pathways, and a few other structures. Of the two hydroxylated isomeres which were shown to be equally psychoactive the brain concentration of 11-OH-delta9-THC was found to be about 3 times higher as compared with 11-OH-delta8 THC, which may explain why delta9-THC is more potent than delta8-THC. More than 90% of the radioactivity found in the brain can be attributed to the THCs and their 11-hydroxylated isomeres. Polar metabolites are almost completely absent from the brain.

摘要

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本文引用的文献

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Corticosterone elevation mediated centrally by delta 1-tetrahydrocannabinol in rats.
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