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δ9-四氢大麻酚在小鼠体内的分布。

Distribution of delta 9-tetrahydrocannabinol in the mouse.

作者信息

Freudenthal R I, Martin J, Wall M E

出版信息

Br J Pharmacol. 1972 Feb;44(2):244-9. doi: 10.1111/j.1476-5381.1972.tb07260.x.

DOI:10.1111/j.1476-5381.1972.tb07260.x
PMID:4668591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666058/
Abstract
  1. The distribution of Delta(9)-tetrahydrocannabinol-(14)C in the pregnant and nonpregnant mouse is very similar. High concentrations of radiolabel can be seen in the maternal liver, spleen, lungs, brown fat, adrenal glands, mammary glands, yolk sac placenta and corpora lutea. In the pregnant mouse Delta(9)-THC crosses the placenta and enters the foetuses in very low concentrations, with no apparent selective intrafoetal radiolabel accumulation sites. Autoradiograms showing the distribution of (14)C-cannabinoid 2 h after dosing are presented.2. A small amount of maternal liver and foetal tissue was removed from the mice, used for autoradiography and extracted with ethyl acetate. Most of the radiolabel in these tissues was solvent extractable and was separated by thin layer chromatography into two fractions, THC and metabolites.3. It appears that most of the cannabinoid is present in a free rather than conjugated form.
摘要

  1. 孕鼠和未孕鼠体内Δ⁹-四氢大麻酚-¹⁴C的分布非常相似。在母体的肝脏、脾脏、肺、棕色脂肪、肾上腺、乳腺、卵黄囊胎盘和黄体中可见高浓度的放射性标记物。在孕鼠中，Δ⁹-THC穿过胎盘并以极低浓度进入胎儿体内，胎儿体内没有明显的放射性标记物选择性积累部位。文中给出了给药2小时后¹⁴C-大麻素分布的放射自显影片。

  2. 从小鼠身上取出少量母体肝脏和胎儿组织，用于放射自显影，并用乙酸乙酯提取。这些组织中的大部分放射性标记物可被溶剂萃取，并通过薄层色谱法分离为两个部分，即THC和代谢物。

  3. 似乎大部分大麻素以游离形式而非结合形式存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/0b91f8ca958d/brjpharm00486-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/7d363fffd45e/brjpharm00486-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/80cd4b2b8af7/brjpharm00486-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/0b91f8ca958d/brjpharm00486-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/7d363fffd45e/brjpharm00486-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/80cd4b2b8af7/brjpharm00486-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd3f/1666058/0b91f8ca958d/brjpharm00486-0090-a.jpg

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本文引用的文献

1
Isolation of trans-delta-tetrahydrocannabinol from marijuana.
J Am Chem Soc. 1966 Apr 20;88(8):1832-3. doi: 10.1021/ja00960a056.
2
Comparison of tetrahydrocannabinol and synhexyl in man.四氢大麻酚与人造己基环己基乙炔的人体比较。
Clin Pharmacol Ther. 1968 Nov-Dec;9(6):783-91. doi: 10.1002/cpt196896783.
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The Ullberg technique of whole body autoradiography.全身放射自显影的乌尔贝里技术。
J Biol Photogr Assoc. 1967 Nov;35(4):147-54.
Adv Exp Med Biol. 2023;1428:199-232. doi: 10.1007/978-3-031-32554-0_9.
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Effect of Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells.Δ9-四氢大麻酚和大麻二酚对 HC11 细胞中乳蛋白和脂质水平的影响。
PLoS One. 2022 Aug 17;17(8):e0272819. doi: 10.1371/journal.pone.0272819. eCollection 2022.
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Detection of Exposure to Cannabis in Paired Umbilical Cord Tissue and Meconium by Liquid Chromatography-Tandem Mass Spectrometry.采用液相色谱-串联质谱法检测脐带组织和胎粪中大麻暴露情况。
Clin Mass Spectrom. 2019 Jan 24;14 Pt B:115-123. doi: 10.1016/j.clinms.2019.01.002. eCollection 2019 Nov.
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Marijuana Use in Pregnancy: A Review.孕期大麻使用：综述。
Obstet Gynecol Surv. 2019 Jul;74(7):415-428. doi: 10.1097/OGX.0000000000000685.
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Cannabis use during pregnancy: Pharmacokinetics and effects on child development.孕期使用大麻：药代动力学和对儿童发育的影响。
Pharmacol Ther. 2018 Feb;182:133-151. doi: 10.1016/j.pharmthera.2017.08.014. Epub 2017 Aug 25.
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Psychopharmacology (Berl). 1980;70(2):155-61. doi: 10.1007/BF00435307.
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Proc R Soc Med. 1973 Jul;66(7):722. doi: 10.1177/003591577306600753.
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Effects of tetrahydrocannabinol on rat preovulatory follicles: a quantitative cytochemical analysis.四氢大麻酚对大鼠排卵前卵泡的影响：定量细胞化学分析
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J Am Chem Soc. 1970 Jun 3;92(11):3466-8. doi: 10.1021/ja00714a042.
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