Noble W, Delini-Stula A
Psychopharmacology (Berl). 1976 Aug 26;49(1):17-22. doi: 10.1007/BF00427465.
The effect of oxprenolol (100 mg/kg p.o.) on the development of hyperthermia in a shock enclosure and on exploratory and grooming responses in an exploration box, was investigated in rats subjected to inescapable shocks once daily for 5 days. The hyperthermic response of shocked rats was found to be significantly reduced by oxprenolol treatment. Exploratory behavior, which was suppressed by previous exposure to shocks, was not influenced by oxprenolol. However, under oxprenolol treatment grooming diminished from the first day of the trial onward, both in duration and frequency, as though habituation had occurred. The results are interpreted as evidence of partial effectiveness of oxprenolol in suppressing fear-induced somatic and behavioral manifestations.
研究了氧烯洛尔（100毫克/千克口服）对处于休克环境中大鼠体温过高发展的影响，以及对处于探索箱中大鼠探索和梳理反应的影响。对大鼠每天进行一次不可逃避的电击，持续5天。发现氧烯洛尔治疗可显著降低受电击大鼠的体温过高反应。先前电击抑制的探索行为不受氧烯洛尔影响。然而，在氧烯洛尔治疗下，从试验第一天起，梳理行为在持续时间和频率上均减少，就好像已经发生了习惯化。结果被解释为氧烯洛尔在抑制恐惧引起的躯体和行为表现方面部分有效的证据。
