Francès H, Puech A J, Chermat R, Simon P
Psychopharmacology (Berl). 1979 May 8;63(1):43-8. doi: 10.1007/BF00426920.
Common effects of four beta-adrenergic blocking drugs have been investigated in mice using classical and new psychopharmacological tests. Propranolol, alprenolol, practolol and penbutolol reduced the increase in locomotor activity produced by reserpine after MAO inhibition; they produce hypothermia when associated with amphetamine and they increase oxotremorine-induced hypothermia. Regarding these three tests the studied substances ranged themseleves in the same order of potency: penbutolol greater than propranolol greater than alprenolol greater than practolol. Propranolol and penbutolol decreased the toxicity provoked in crowded mice by amphetamine or by the association pargyline-reserpine; alprenolol and practolol did not. Propranolol, penbutolol and alprenolol antagonized the amphetamine-induced increase in motor activity; practolol did not. When used at doses for which d-l propranolol was active, the dextrogyre isomer of propranolol was without effect whatever the test studied. It is suggested that for the selection of a beta-blocking drug, regarding central effects in man, the tests described would deserve consideration.
利用经典和新的心理药理学测试，在小鼠身上研究了四种β-肾上腺素能阻断药物的常见效应。普萘洛尔、阿普洛尔、普拉洛尔和喷布洛尔在单胺氧化酶抑制后，降低了利血平所引起的自发活动增加；当与苯丙胺联用时，它们会引起体温过低，并且会增强毒蕈碱引起的体温过低。就这三项测试而言，所研究的物质按效力顺序排列相同：喷布洛尔大于普萘洛尔大于阿普洛尔大于普拉洛尔。普萘洛尔和喷布洛尔降低了苯丙胺或帕吉林-利血平联用在拥挤小鼠中所引发的毒性；阿普洛尔和普拉洛尔则没有。普萘洛尔、喷布洛尔和阿普洛尔拮抗了苯丙胺引起的运动活动增加；普拉洛尔则没有。当以d-1普萘洛尔有活性的剂量使用时，无论所研究的测试如何，普萘洛尔的右旋异构体均无作用。有人提出，就人类的中枢效应而言，为选择β-阻断药物，所描述的测试值得考虑。
