噻吩甲酰三氟丙酮诱导大鼠肝线粒体脂质过氧化。
Thenoyltrifluoracetone induces lipid peroxidation in rat liver mitochondria.
作者信息
Gogvadze V, Zhukova A
机构信息
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
出版信息
Gen Physiol Biophys. 1993 Jun;12(3):303-8.
PMID:8224786
Abstract
Addition of thenoyltrifluoracetone to mitochondria oxidizing NAD-dependent substrates induced lipid peroxidation and uncoupling of oxidative phosphorylation. Butylated hydroxytoluene, an antioxidant, prevented accumulation of lipid peroxidation products but failed to prevent deenergization of the mitochondria.
摘要
将噻吩甲酰三氟丙酮添加到氧化依赖于NAD的底物的线粒体中，会诱导脂质过氧化和氧化磷酸化解偶联。抗氧化剂丁基羟基甲苯可防止脂质过氧化产物的积累，但未能阻止线粒体的能量耗散。
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