[磷脂酶A2参与脂质过氧化产物诱导的大鼠肝线粒体解偶联作用]
[Participation of phospholipase A2 in uncoupling in rat liver mitochondria induced by products of lipid peroxidation].
作者信息
Gogvadze V G, Bruetovetskiĭ N N, Zhukova A A
出版信息
Biokhimiia. 1990 Dec;55(12):2195-9.
PMID:2129018
Abstract
Accumulation of lipid peroxidation products induced by cumol hydroperoxide (230 microM) results in the loss of the membrane potential only in calcium-loaded mitochondria. The phospholipase A2 inhibitor, p-bromophenylacylbromide, prevents mitochondrial uncoupling but has no effect on the accumulation of lipid peroxidation products.
摘要
氢过氧化枯茗（230微摩尔）诱导的脂质过氧化产物积累仅在钙负载的线粒体中导致膜电位丧失。磷脂酶A2抑制剂对溴苯酰溴可防止线粒体解偶联，但对脂质过氧化产物的积累没有影响。
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