Garriga G, Guenther C, Horvitz H R
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Genes Dev. 1993 Nov;7(11):2097-109. doi: 10.1101/gad.7.11.2097.
During embryonic development, the two Caenorhabditis elegans HSN motor neurons migrate from their birthplace in the tail to positions near the middle of the embryo. Here, we demonstrate that of all cells that undergo long-range migrations, only the HSNs are affected in animals that lack function of the egl-43 gene. We also show that egl-43 function is required for normal development of phasmid neurons, which are sensory neurons located in the tail. The egl-43 gene encodes two proteins containing zinc finger motifs that are similar to the zinc fingers of the murine Evi-1 proto-oncoprotein. Our genetic and molecular results suggest that egl-43 encodes two transcription factors and acts to control HSN migration and phasmid neuron development, presumably by regulating other genes that function directly in these processes.
在胚胎发育过程中，秀丽隐杆线虫的两个HSN运动神经元从其在尾部的起源位置迁移到胚胎中部附近的位置。在这里，我们证明，在所有经历长距离迁移的细胞中，只有HSN在缺乏egl-43基因功能的动物中受到影响。我们还表明，egl-43功能是位于尾部的感觉神经元——咽侧体神经元正常发育所必需的。egl-43基因编码两种含有锌指基序的蛋白质，这些锌指与小鼠Evi-1原癌蛋白的锌指相似。我们的遗传和分子结果表明，egl-43编码两种转录因子，并通过调控直接参与这些过程的其他基因来控制HSN迁移和咽侧体神经元发育。
