Umlauf S W, Beverly B, Kang S M, Brorson K, Tran A C, Schwartz R H
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892.
Immunol Rev. 1993 Jun;133:177-97. doi: 10.1111/j.1600-065x.1993.tb01516.x.
The delivery of costimulation and the effects of the anergic state impinge on IL-2 production via different molecular mechanisms. The strongest experimental support at this stage suggests that CD28 signaling effects mRNA stability of several lymphokine genes including IL-2. While there may also be transcriptional effects of CD28 signals in human cells, controversy surrounding relevant TCR mimics must be addressed. In the case of clonal anergy, however, transcriptional non-responsiveness is evident when anergic cells are restimulated with TCR and costimulatory signals. This repression affects predominantly AP-1 activity. So far, the nature of the repression has not been identified.
共刺激的传递以及无反应状态的影响通过不同的分子机制影响白细胞介素-2（IL-2）的产生。现阶段最有力的实验证据表明，CD28信号传导影响包括IL-2在内的几种淋巴因子基因的mRNA稳定性。虽然在人类细胞中CD28信号可能也存在转录效应，但必须解决围绕相关T细胞受体模拟物的争议。然而，在克隆无反应的情况下，当无反应细胞用T细胞受体和共刺激信号再次刺激时，转录无反应是明显的。这种抑制主要影响激活蛋白-1（AP-1）的活性。到目前为止，这种抑制的本质尚未确定。
