Srikanth V, Aruldhas M M, Balasubramanian K, Udayakumar R C, Antony F F, Govindarajulu P
Department of Endocrinology, Dr ALM PGIBMS, Taramani, University of Madras, India.
Indian J Exp Biol. 1993 Jul;31(7):587-9.
Hypothyroidism (surgical thyroidectomy) inhibited the activities of acid phosphatase and Mg(2+)-ATPase in seminal vesicular tissue and fluid and that of Ca(2+)- and Na+/K(+)-ATPases in fluid alone, and T4 supplementation restored normalcy in all, except acid phosphatase. Hyperthyroidism (T4 25 micrograms/100g body weight/day for 60 days, im) enhanced the activities of alkaline phosphatase and ATPases in seminal vesicular tissue and fluid, and decreased acid phosphatase activity in tissue alone. Withdrawal of T4 treatment from hyperthyroid rats (after 30 days) augmented the activity of ATPases in tissue and impaired the same in fluid, while phosphomonoesterases remained at hyperthyroid level. The results suggest specific responses of various seminal vesicular phosphatases to altered thyroid hormone status. Modification in the specific threshold of androgen/estrogen action on different phosphatases in seminal vesicles appears to be the plausible mechanism underlying these changes in hypo- and hyperthyroid conditions.
甲状腺功能减退（手术切除甲状腺）抑制了精囊组织和精囊液中酸性磷酸酶和镁离子 - ATP酶的活性，以及仅精囊液中钙离子 - ATP酶和钠钾离子 - ATP酶的活性，补充甲状腺素（T4）后，除酸性磷酸酶外，其他酶活性均恢复正常。甲状腺功能亢进（每天腹腔注射25微克/100克体重的T4，持续60天）增强了精囊组织和精囊液中碱性磷酸酶和ATP酶的活性，且仅降低了精囊组织中酸性磷酸酶的活性。对甲状腺功能亢进大鼠停止T4治疗（30天后），精囊组织中ATP酶的活性增强，而精囊液中的ATP酶活性受损，同时磷酸单酯酶活性维持在甲状腺功能亢进水平。结果表明，精囊中各种磷酸酶对甲状腺激素状态改变有特异性反应。雄激素/雌激素对精囊中不同磷酸酶作用的特定阈值改变似乎是甲状腺功能减退和亢进状态下这些变化的潜在合理机制。
