Santha T, Fox W, Nazareth O, Prabhakar R, Radhakrishna S, Ramakrishnan C V, Sivasubramanian S, Somasundaram P R, Tripathy S P
Tubercle. 1976 Jun;57(2):123-30. doi: 10.1016/0041-3879(76)90049-0.
A once-weekly regimen of streptomycin (1 g) plus a slow-release preparation of isoniazid (matrix isoniazid) in high dosage, namely 50 mg/kg body-weight for rapid inactivators of isoniazid and 35 mg/kg for slow inactivators, was prescribed for 6 months to 64 tuberculous patients (27 rapid, 37 slow). The regimen was tolerated by most the of the patients. However, 4 rapid and 3 slow inactivators had a modification of the regimen, mainly for giddiness. There were no cases of peripheral neuropathy. No adverse effects on haemopoiesis or hepatic or renal functions were observed in any of the patients. It is concluded that it is feasible to administer matrix isoniazid in dosages considerably higher than ordinary isoniazid, in once-weekly chemotherapy.
对64例结核病患者（27例快灭活者，37例慢灭活者）采用每周1次的链霉素（1克）加高效缓释异烟肼制剂（基质异烟肼）方案，即快灭活者按体重50毫克/千克、慢灭活者按体重35毫克/千克给药，疗程6个月。大多数患者耐受该方案。然而，4例快灭活者和3例慢灭活者对方案进行了调整，主要是因为头晕。未出现周围神经病变病例。所有患者均未观察到对造血、肝肾功能的不良影响。结论是，在每周1次的化疗中，给予远高于普通异烟肼剂量的基质异烟肼是可行的。
