Parthasarathy R, Devadatta S, Fox W, Krishnaswami K V, Radhakrishna S, Somasundaram P R, Tripathy S P
Tubercle. 1976 Jun;57(2):115-21. doi: 10.1016/0041-3879(76)90048-9.
'Double-blind' studies were carried out to assess the incidence of immediate adverse reactions to different doses of a slow-release preparation of isoniazid (matrix isoniazid). Individual doses of 30 mg/kg matrix isoniazid were well-tolerated but higher doses resulted in giddiness, the incidence being dose-related. The giddiness was characterized by a late onset and was usually present even at 24 hours. A few patients complained of gastro-intestinal symptoms. It is concluded that matrix isoniazid can be given to Madras patients in doses of 30-40 mg/kg without risk of an undue incidence of immediate adverse reactions.
