Spina E, Pollicino A M, Avenoso A, Campo G M, Caputi A P
Institute of Pharmacology, University of Messina, Italy.
Int J Clin Pharmacol Res. 1993;13(3):167-71.
The effect of fluvoxamine maleate, 100 mg/day for 10 days, on plasma concentrations of tricyclic antidepressants was studied in 15 depressed patients on maintenance therapy with imipramine (7 pts.) or desipramine (8 pts.). In the subgroup treated with imipramine, plasma levels of imipramine increased significantly (p < 0.001) during fluvoxamine coadministration, while levels of desipramine were not modified. Addition of fluvoxamine to patients on a stable desipramine dosage regimen resulted in a slight, but statistically not significant, increase in desipramine plasma concentrations. These results suggest that fluvoxamine is a potent inhibitor of imipramine demethylation, while it has a weak effect on the hydroxylation of desipramine.
在15例接受丙咪嗪（7例）或地昔帕明（8例）维持治疗的抑郁症患者中，研究了每天100毫克马来酸氟伏沙明连续服用10天对三环类抗抑郁药血浆浓度的影响。在接受丙咪嗪治疗的亚组中，联合使用氟伏沙明期间丙咪嗪的血浆水平显著升高（p < 0.001），而地昔帕明的水平未发生改变。在稳定服用地昔帕明剂量方案的患者中添加氟伏沙明，导致地昔帕明血浆浓度略有升高，但在统计学上无显著意义。这些结果表明，氟伏沙明是丙咪嗪去甲基化的强效抑制剂，而对去甲丙咪嗪的羟基化作用较弱。
