Benoiton N L, Lee Y C, Chen F M
Department of Biochemistry, University of Ottawa, Ontario, Canada.
Int J Pept Protein Res. 1993 Sep;42(3):278-83. doi: 10.1111/j.1399-3011.1993.tb00143.x.
Generation of a mixed anhydride using ethyl or isopropyl chloroformate and N-methylmorpholine in dichloromethane at room temperature, followed by addition of excess ring-substituted phenol or N-substituted hydroxylamine and a catalytic amount of tertiary amine, provides an efficient synthesis of activated esters.
在室温下于二氯甲烷中使用氯甲酸乙酯或氯甲酸异丙酯与N-甲基吗啉生成混合酸酐，随后加入过量的环取代苯酚或N-取代羟胺以及催化量的叔胺，可实现活性酯的高效合成。
