Jansen T, Kossmann E, Plewig G
Dermatologische Klinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1993 Oct;44(10):636-43.
In plastic-reconstructive surgery in recent decades silicone fluid has been injected for cosmetic reasons and has occasionally led to granulomas with foreign body reaction (siliconoma). A 77-year-old woman is presented who developed protuberant facial granulomas 15 years after the injection of silicone fluid to improve scars. Histopathology revealed large lipid-filled cells, surrounded by histiocytic cells and foreign body giant cells. Laser microprobe mass analysis (LAMMA) showed peaks consistent with PO2 and PO3, which are usually found in regions of foreign body reactions. Treatment with isotretinoin given orally in low doses (20 mg total dose per day) resulted in a complete resolution of the granulomas. The anti-inflammatory action of isotretinoin was the reason for selecting this treatment modality.
近几十年来，在整形重建手术中，出于美容目的注射了硅油，偶尔会导致伴有异物反应的肉芽肿（硅瘤）。本文介绍了一名77岁女性，她在注射硅油以改善瘢痕15年后出现了突出的面部肉芽肿。组织病理学显示有大量充满脂质的细胞，周围是组织细胞和异物巨细胞。激光微探针质谱分析（LAMMA）显示出与PO2和PO3一致的峰，这通常在异物反应区域中发现。低剂量口服异维A酸（每天总剂量20 mg）治疗使肉芽肿完全消退。选择这种治疗方式的原因是异维A酸的抗炎作用。
