Convery Cormac, Davies Emma, Murray Gillian, Walker Lee
Dr. Convery is with The Ever Clinic Glasgow in Glasgow, Scotland.
Ms. Davies is the Clinical Director of Save Face UK.
J Clin Aesthet Dermatol. 2021 Jul;14(7):E59-E67. Epub 2021 Jul 1.
Delayed-onset nodules (DONs) represent a poorly understood and generally neglected group of complications. It is not a diagnosis. The underlying pathologies and their incidences are largely unknown due to the lack of specificity in clinical signs and the challenges in accessing diagnostic tests, cost implications, or reluctance from patients to undergo them. A lack of presumptive clinical diagnosis, coupled with management ranging from "scatter-gun" polypharmacy to clinical inertia, is believed to result in chronicity and increased morbidity. This paper provides guidance on the identification and understanding of the underlying pathologies and encourages the increased utilization of a medical model of care. The more routine adoption of histopathology, inflammatory markers, and ultrasound will permit a more targeted management and a greater understanding of the incidences and evolution of the pathologies.
迟发性结节（DONs）是一类理解不足且普遍被忽视的并发症。它并非一种诊断。由于临床体征缺乏特异性，以及获取诊断检测存在挑战、成本问题或患者不愿接受检测，其潜在病理情况及其发生率在很大程度上尚不明确。据信，缺乏初步临床诊断，再加上从“散弹枪式”联合用药到临床惰性的管理方式，会导致病情慢性化和发病率增加。本文就潜在病理情况的识别与理解提供指导，并鼓励更多地采用医疗照护模式。更常规地采用组织病理学、炎症标志物和超声检查将有助于进行更有针对性的管理，并更深入地了解这些病理情况的发生率和演变过程。
