Three sickle cell anemia patients each with a different alpha chain variant. Diagnostic complications.

作者信息

Gu L H, Wilson J B, Molchanova T P, McKie K M, McKie V C, Huisman T H

机构信息

Department of Biochemistry and Molecular Biology Medical College of Georgia, Augusta 30912-2100.

出版信息

Hemoglobin. 1993 Aug;17(4):295-301. doi: 10.3109/03630269308997483.

We have studied three sickle cell anemia patients who also carried a heterozygosity for one of the following alpha chain abnormalities: Hb G-Philadelphia [alpha 68(E17)Asn-->Lys], Hb Montgomery [alpha 48 (CE6)Leu-->Arg], and Hb Chicago [alpha 136(H19)Leu-->Met]. Electrophoretic analyses alone may result in incomplete and incorrect information. Confirmation of the diagnosis of Hb SS or Hb SC disease by one of the fast high performance liquid chromatographic procedures is recommended.