Afolabi S K, Tulloch B R, Kissebah A H, Vydelingum N, Fraser T R
Clin Endocrinol (Oxf). 1976 May;5(3):203-8. doi: 10.1111/j.1365-2265.1976.tb01946.x.
The role of the adrenal cortex in the pathogenesis of hypertriglyceridaemia associated with the intake of oral contraceptive agents containing oestrogen has been investigated in rats. Bilateral adrenalectomy reduced the activity of hepatic enzymes regulating lipogenesis (acetyl CoA carboxylase, fatty acid synthetase) and decreased plasma triglyceride concentrations. On the other hand, the administration of high dosage corticosterone induced the activity of hepatic enzymes with consequent elevation in serum triglyceride levels. In animals with intact adrenals the administration of oestradiol: (a) raised plasma triglyceride levels, (b) enhanced the activity of hepatic enzymes, and (c) increased the adrenal cortex:body weight ratio. The effects (a) and (b) were not observed when both adrenals were removed prior to oestrogen therapy. High dosage corticosterone replacement was found to be essential for the oestradiol to produce its effects on hepatic enzymes and plasma triglyceride levels. The results suggest a regulatory role for the adrenal cortex in the homeostasis of plasma triglyceride concentration and that the hypertriglyceridaemia induced by the oestrogen containing preparations might be secondary to alterations in adrenocortical function.
在大鼠中研究了肾上腺皮质在与摄入含雌激素的口服避孕药相关的高甘油三酯血症发病机制中的作用。双侧肾上腺切除术降低了调节脂肪生成的肝酶（乙酰辅酶A羧化酶、脂肪酸合成酶）的活性，并降低了血浆甘油三酯浓度。另一方面，给予高剂量皮质酮可诱导肝酶活性，从而导致血清甘油三酯水平升高。在肾上腺完整的动物中，给予雌二醇：（a）提高血浆甘油三酯水平，（b）增强肝酶活性，（c）增加肾上腺皮质与体重的比值。在雌激素治疗前切除双侧肾上腺时，未观察到（a）和（b）效应。发现高剂量皮质酮替代对于雌二醇对肝酶和血浆甘油三酯水平产生影响至关重要。结果表明肾上腺皮质在血浆甘油三酯浓度稳态中起调节作用，并且含雌激素制剂诱导的高甘油三酯血症可能继发于肾上腺皮质功能改变。
