精神分裂症患者呼出气体中戊烷和二硫化碳增加。
Increased pentane and carbon disulfide in the breath of patients with schizophrenia.
作者信息
Phillips M, Sabas M, Greenberg J
机构信息
Department of Medicine, St Vincent's Medical Center of Richmond, Staten Island, New York 10310-1699.
出版信息
J Clin Pathol. 1993 Sep;46(9):861-4. doi: 10.1136/jcp.46.9.861.
Abstract
AIMS
To determine the concentrations of pentane (a marker of lipid peroxidation) and other volatile organic compounds in the breath of patients with schizophrenia.
METHODS
Volatile organic compounds were assayed by gas chromatography/mass spectroscopy (GC/MS) in 88 subjects--25 with acute schizophrenic psychosis, 26 with psychiatric disorders other than schizophrenia, and 37 normal volunteers.
RESULTS
The mean alveolar gradients of pentane and carbon disulfide (CS2) were significantly higher in the patients with schizophrenia than in the control groups.
CONCLUSIONS
Schizophrenia may be accompanied by accelerated lipid peroxidation in cell membranes, as well as increased manufacture of CS2, a known neurotoxin.
摘要
目的
测定精神分裂症患者呼出气体中戊烷（脂质过氧化标志物）及其他挥发性有机化合物的浓度。
方法
采用气相色谱/质谱联用仪（GC/MS）对88名受试者进行挥发性有机化合物检测，其中25例为急性精神分裂症患者，26例为除精神分裂症外的其他精神疾病患者，37例为正常志愿者。
结果
精神分裂症患者戊烷和二硫化碳（CS2）的平均肺泡梯度显著高于对照组。
结论
精神分裂症可能伴有细胞膜脂质过氧化加速以及已知神经毒素CS2生成增加。
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