Henry M A, Westrum L E, Bothwell M, Johnson L R
Department of Neurological Surgery, University of Washington, Seattle 98195.
J Comp Neurol. 1993 Sep 15;335(3):425-36. doi: 10.1002/cne.903350311.
The 75 kDa protein nerve growth factor receptor [NGFr(p75)] is a neurotrophin receptor that is able to bind different members of the neurotrophin family of molecules implicated in affecting neuronal survival. Here we describe the light microscopic distribution of NGFr(p75)-immunoreactivity (IR) within the feline trigeminal brainstem sensory nuclear complex and trigeminal ganglion of normal adult subjects and in subjects 10 and 30 days following retrogasserian rhizotomy. Within the trigeminal ganglion of normal subjects, numerous fibers and most of the neuronal cell bodies showed NGFr(p75)-IR that varied in intensity, while cells and fibers with NGFr(p75)-IR were less numerous within the mesencephalic trigeminal nucleus. Within the main sensory and spinal trigeminal nuclei, NGFr(p75)-IR formed a reproducible pattern that varied between the different subnuclei. The NGFr(p75)-IR consisted both of dense pockets and a low level NGFr(p75)-IR that was selective to the trigeminal neuropil. Following rhizotomy, most of the NGFr(p75)-IR was lost from the main sensory and spinal trigeminal nuclei, except in regions where the upper cervical roots and cranial nerves VII, IX, and X project. In contrast, examination of the central root that was still attached to the trigeminal ganglion showed increased NGFr(p75)-IR in fibers and supporting cells, as did the motor root within the peripheral mandibular division. These results indicate that the majority of the NGFr(p75)-IR within the main sensory and spinal trigeminal nuclei originates from primary trigeminal afferents and that retrogasserian rhizotomy leads to an up-regulation of NGFr(p75)-IR in the part of the central root that is contiguous with the ganglion.
75kDa蛋白神经生长因子受体[NGFr(p75)]是一种神经营养因子受体，能够结合神经营养因子家族中不同的分子成员，这些分子与影响神经元存活有关。在此，我们描述了正常成年猫三叉神经脑干感觉核复合体和三叉神经节内以及半月节后根切断术后10天和30天的猫中NGFr(p75)免疫反应性(IR)的光镜分布。在正常猫的三叉神经节内，许多纤维和大多数神经元细胞体显示出强度不同的NGFr(p75)-IR，而中脑三叉神经核内具有NGFr(p75)-IR的细胞和纤维较少。在主要感觉核和三叉神经脊束核内，NGFr(p75)-IR形成了一种可重复的模式，不同亚核之间存在差异。NGFr(p75)-IR由密集区和对三叉神经神经毡有选择性的低水平NGFr(p75)-IR组成。根切断术后，除了上颈神经根以及脑神经VII、IX和X投射的区域外，主要感觉核和三叉神经脊束核内的大部分NGFr(p75)-IR消失。相反，对仍与三叉神经节相连的中枢根进行检查发现，纤维和支持细胞中的NGFr(p75)-IR增加，下颌神经外周分支内的运动根也是如此。这些结果表明，主要感觉核和三叉神经脊束核内的大部分NGFr(p75)-IR源自三叉神经初级传入纤维，半月节后根切断术导致与神经节相邻的中枢根部分的NGFr(p75)-IR上调。
