Bartlett J D, Wesson M D, Swiatocha J, Woolley T
School of Optometry, University of Alabama at Birmingham 35294.
J Am Optom Assoc. 1993 Sep;64(9):617-21.
The topical administration of eyedrops is often an unpleasant procedure in the pediatric population. We sought to learn whether a combination mydriatic-cycloplegic solution would be an effective cycloplegic if delivered as a spray.
We conducted a prospective, examiner-masked, parallel-group study and randomized 38 subjects (age range 6 months to 12 years, mean = 7.3 years) into four groups such that the same combination mydriatic-cycloplegic solution was administered under the following conditions: 1) eyedrops to eyes that were open; 2) eyedrops to eyes that were closed; 3) spray to eyes that were open; 4) spray to eyes that were closed. Both eyes of each subject received the solutions administered under one of the four conditions. Residual accommodation was measured using dynamic retinoscopy and the subjective push-up method, where applicable, at times 0, 10, 20, 30, 45, and 60 mins following administration of the medications.
Repeated measures analysis of covariance revealed no statistically significant difference (p > 0.05) in cycloplegic efficacy among the four methods of drug delivery.
The results of this study suggest that administering cycloplegics by spray to the closed eye is as efficacious as instilling eyedrops to the open eye. Use of a cycloplegic spray can have important clinical advantages compared to conventional cycloplegic eyedrops administered to children.
在儿科人群中，局部滴眼药水常常是一个令人不适的过程。我们试图了解散瞳-睫状肌麻痹联合溶液以喷雾形式给药时是否会成为一种有效的睫状肌麻痹剂。
我们进行了一项前瞻性、检查者盲法、平行组研究，将38名受试者（年龄范围6个月至12岁，平均7.3岁）随机分为四组，使同一种散瞳-睫状肌麻痹联合溶液在以下条件下给药：1）滴入睁开的眼睛；2）滴入闭合的眼睛；3）喷入睁开的眼睛；4）喷入闭合的眼睛。每个受试者的双眼接受四种条件之一给药的溶液。在给药后0、10、20、30、45和60分钟时，视情况使用动态视网膜检影法和主观上推法测量残余调节。
重复测量协方差分析显示，四种给药方法在睫状肌麻痹效果上无统计学显著差异（p>0.05）。
本研究结果表明，向闭合的眼睛喷雾给药睫状肌麻痹剂与向睁开的眼睛滴入眼药水效果相同。与给儿童使用传统的睫状肌麻痹眼药水相比，使用睫状肌麻痹喷雾可能具有重要的临床优势。
