Zanchetti A, Sleight P, Birkenhäger W H
Istituto di Clinica Medica, University of Milan, Italy.
J Hypertens. 1993 Aug;11(8):875-82. doi: 10.1097/00004872-199308000-00015.
This document is the result of discussions held during a Scientific Workshop in Brescia, Italy, where the numerous methods, old and new, for evaluation of organ damage in hypertension were considered. Not all of the methods can be recommended as routine diagnostic procedures for every hypertensive subject. Current routine diagnosis of organ damage by clinic blood pressure, retinal appearances, the electrocardiogram, serum creatinine estimation and urinary analysis will probably suffice; of the more refined methods, only the echocardiogram is likely to be often included in the examination of hypertensive patients. All of the other techniques will be useful in the diagnostic approach to patients with particular problems, or for the purposes of special investigation.
It is recommended that the validity of the methods, the clinical relevance of the abnormalities (including left ventricular hypertrophy, reduced coronary reserve, arterial changes in the eye grounds, reduced large artery compliance and microalbuminuria) and the potential benefits of therapeutically reverting these alterations should be assessed by including organ damage evaluation in future epidemiological and interventional trials in hypertension.
本文档是在意大利布雷西亚举行的一次科学研讨会上讨论的结果，会上审议了评估高血压器官损伤的众多新旧方法。并非所有方法都可推荐作为每位高血压患者的常规诊断程序。目前通过诊所血压、视网膜表现、心电图、血清肌酐估计和尿液分析进行器官损伤的常规诊断可能就足够了；在更精细的方法中，只有超声心动图可能经常被纳入高血压患者的检查中。所有其他技术将有助于处理有特殊问题的患者的诊断方法，或用于特殊调查目的。
建议在未来高血压的流行病学和干预试验中纳入器官损伤评估，以评估这些方法的有效性、异常情况（包括左心室肥厚、冠状动脉储备减少、眼底动脉变化、大动脉顺应性降低和微量白蛋白尿）的临床相关性以及治疗性逆转这些改变的潜在益处。
