Hostetter M K
Department of Pediatrics, University of Minnesota Medical School.
J Lab Clin Med. 1993 Nov;122(5):491-6.
The present review has evaluated four biologic processes in which the participation of C3 as a primary mediator deserves more extensive investigation. These novel functions of C3 derive in part from the biochemistry ascribable to a thiolester-containing protein and are underscored by its remarkably high concentration in plasma and widespread presence in tissues. Such physiologic characteristics argue that we have only begun to understand the functions of this most versatile complement protein. The availability of full-length cDNA and the ability to manipulate the C3 gene in tissue culture or embryonic stem cells should help to illuminate the pluripotent nature of this fascinating protein.
本综述评估了四种生物学过程，其中C3作为主要介质的参与值得更广泛的研究。C3的这些新功能部分源于含硫酯蛋白的生物化学特性，其在血浆中的高浓度和在组织中的广泛存在也突出了这一点。这些生理特征表明，我们才刚刚开始了解这种功能最多样化的补体蛋白的功能。全长cDNA的可得性以及在组织培养或胚胎干细胞中操纵C3基因的能力，应有助于阐明这种迷人蛋白质的多能性质。
